The amount of Botox, even in small doses, has been used millions of times with no reports of kidney or liver damage. Mayo Clinic does not endorse companies or products. Advertising Revenue Supports Our Nonprofit Mission. Botox works by blocking the nerve signals that cause muscles to contract.
This prevents wrinkles from forming and relaxes existing wrinkles. We studied 54,335 people who take Botox or have liver cirrhosis and found no reports of liver cirrhosis. Botox is a popular cosmetic treatment used to reduce wrinkles and expression lines. It can also be used to weaken certain muscles in younger clients as a preventive measure. In addition, Botox is also used to treat excessive sweating and cervical dystonia.
In terms of safety, the most commonly reported adverse reactions following Botox injection are dysphagia, upper respiratory tract infection, neck pain, headache, muscle weakness, and eyelid ptosis. However, the doses used are significantly lower than the toxic dose that would be systemically harmful. In a study of patients with blepharospasm who received an average dose per eye of 33 units (injected at 3 to 5 sites) of the currently manufactured Botox, the most commonly reported adverse reactions were ptosis (21%), superficial punctate keratitis (6%), and dry eye (6%). In addition, there have been reports of dysphonia in patients who had been treated for cervical dystonia. Two hundred and thirty-one patients enrolled in a double-blind, placebo-controlled study (the study received 300 units to 400 units of Botox) and compared with 233 patients who received placebo.
In this study, the most common adverse events leading to discontinuation of treatment in the Botox group were neck pain, headache, worsening migraine, muscle weakness and eyelid ptosis. In conclusion, Botox is a safe and effective treatment for wrinkles and other conditions when used as directed. However, it is important to be aware of potential side effects and consult with a doctor before using it.
